• Critical care clinics · Apr 2020

    Review

    The Inflammatory and Hemostatic Response in Sepsis and Meningococcemia.

    • Navin P Boeddha, Thomas Bycroft, Simon Nadel, and Jan A Hazelzet.
    • Department of Pediatrics, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Doctor Molewaterplein 40, 3015 GD Rotterdam, The Netherlands.
    • Crit Care Clin. 2020 Apr 1; 36 (2): 391-399.

    AbstractMeningococcemia is notorious for evasion of the host immune system and its rapid progression to fulminant disease, and serves as a unique model for pediatric sepsis. Illness severity is determined by complex interplays among host, pathogen, and environment. The inflammatory host response, including proinflammatory and anti-inflammatory responses in innate and adaptive immunity, skews toward a proinflammatory state. This leads to endothelial dysfunction and activation of the hemostatic response, which may lead to disseminated intravascular coagulation. This article reviews the pathogenesis of sepsis, in particular the inflammatory and hemostatic response in meningococcal sepsis.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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