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Critical care clinics · Apr 2020
ReviewCoagulation Disorders in Hemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome.
- Sandrine Valade, Eric Mariotte, and Elie Azoulay.
- Medical ICU, Saint Louis University Hospital, Assistance Publique des Hôpitaux de Paris, 1 Avenue Claude Vellefaux, 75010 Paris, France. Electronic address: sandrine.valade@aphp.fr.
- Crit Care Clin. 2020 Apr 1; 36 (2): 415-426.
AbstractHemophagocytic lymphohistiocytosis (HLH) is a rare and severe condition that can lead patients to the intensive care unit. HLH diagnosis may be challenging, as it relies on sets of aspecific criteria. Several organ dysfunctions have been described during HLH, including hemostasis impairment found in more than half of the patients. The most frequently reported anomaly is a decrease in the fibrinogen level, which has been associated with higher mortality rates. Coagulation impairment study in patients with HLH represents an interesting field of research, as little is known about the mechanism leading to hypofibrinogenemia.Copyright © 2020 Elsevier Inc. All rights reserved.
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