• Ai Peng Tan.
• Department of Diagnostic Imaging, National University Health System, Singapore. Electronic address: ai_peng_tan@nuhs.edu.sg.
• World Neurosurg. 2020 Jun 1; 138: 158-162.

BackgroundCerebral venous complications related to neurosurgical interventions are only rarely reported in the literature. Internal cerebral veins (ICVs) are vulnerable to injury during neurosurgical approaches to the pineal and thalamic regions. The occurrence of unilateral postoperative ICV thrombosis in children is extremely rare, with only 2 such cases reported thus far.Case DescriptionA 15-year-old child presented to the emergency department with headache, persistent vomiting, and pronounced lethargy for 3 days. Magnetic resonance imaging of the brain was performed and showed a large solid-cystic mass at the pineal region, resulting in upstream hydrocephalus. Serum beta-human chorionic gonadotropin was elevated, and a diagnosis of germ cell tumor was made. Patient was started on neoadjuvant chemotherapy, with partial response on repeat imaging after 3 courses of chemotherapy. Decision was made to proceed with surgical resection of the residual tumor. Magnetic resonance imaging of the brain performed on postoperative day 1 showed multiple foci of restricted diffusion in the right cerebral deep white matter, giving rise to a "string of pearls" appearance. There is also absence of enhancement of the right ICV, suspicious for deep cerebral venous thrombosis. This was confirmed on subsequent computed tomography venogram.ConclusionsOur reported case adds to the limited literature on postoperative ICV thrombosis in children and describes a unique imaging phenotype of venous watershed infarcts. Neurosurgeons and neuroradiologists should be aware of this unique imaging phenotype and have a high index of suspicion for deep cerebral venous thrombosis, especially in patients with prior neurosurgical intervention in the pineal or thalamic regions.Copyright © 2020 Elsevier Inc. All rights reserved.

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