• Matthias Braito, Stephan Wolf, Dietmar Dammerer, Johannes Giesinger, Jürgen Wansch, and Rainer Biedermann.
• Department of Orthopedics, Medical University of Innsbruck, Anichstraße 35, 6020, Innsbruck, Austria.
• Arch Orthop Trauma Surg. 2021 Jan 1; 141 (1): 1-16.

IntroductionGlobal discussions regarding the treatment of Legg-Calvé-Perthes disease (LCPD) are still controversial. The aim of this study was to characterize the worldwide regional differences in nonoperative and operative treatment for LCPD.Materials And MethodsBased on a comprehensive literature search, 123 studies describing the results of nonoperative and operative treatment for LCPD were included. Overall, disease and outcome parameters of 6,968 hips were recorded and compared among the continents-Europe, North America, Asia, Africa, South America, and Australia.ResultsOur results showed that the continents differed regarding initial disease progression and therapeutic decision-making, but the final outcome was comparable. The reported proportion of affected hips with mild presentation tended to be higher in Europe, North America, and Africa, whereas disease progression was more severe in Asia, Australia, and South America. Nonoperative treatment was reported more frequently in Europe and North America, while operative management was more common in the rest of the world. Femoral osteotomy was performed more frequently than pelvic osteotomy worldwide, but pelvic osteotomy was comparably more common in North America, Australia, and South America.ConclusionsThe continents differed in terms of therapies for LCPD, while the final outcome was similar. Studies with greater evidence and larger sample size are needed to evaluate the effect of therapeutic measures on LCPD outcome.Level Of EvidenceIII (systematic review of level III studies).

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