• Marc C Grant-Freemantle, Éanna J Ryan, Sean O Flynn, Darren P Moloney, Michael A Kelly, Eamonn I Coveney, Brendan J O'Daly, and John F Quinlan.
• Departments of Orthopaedics, and.
• J Orthop Trauma. 2020 May 1; 34 (5): 223-230.

ObjectivesTo compare the efficacy of negative pressure wound therapy (NPWT) versus conventional dressings (CD) in the management of open fractures.Data SourcesA systematic search of English articles in the PubMed/MEDLINE, Embase, and the Cochrane Library through April 2019 comparing NPWT versus CD in the management of open fractures.Study SelectionInclusion criteria were articles in English language, comparing NPWT with CD in skeletally mature individuals who had sustained an open fracture at any anatomical site, reporting on rates of deep infection, flap frequency, flap failure, nonunion, amputation, length of hospital, or intensive care unit stay.Data ExtractionTwo authors independently extracted data from selected studies, and the data collected were compared with verify agreement.Data SynthesisPooled odds ratios were calculated for dichotomous outcomes, whereas continuous data were analyzed using the standard weighted mean difference. A random or fixed effect model was used depending on the level of heterogeneity between the studies.ConclusionsNPWT results in decreased likelihood of deep infection and flap failure compared with CD in the management of open fractures not directly amenable to early closure.Level Of EvidenceTherapeutic Level I. See Instructions for Authors for a complete description of levels of evidence.

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