• Jakob M Burgstaller, Maria M Wertli, Nils H Ulrich, Giuseppe Pichierri, Florian Brunner, Mazda Farshad, François Porchet, Johann Steurer, Isaac Gravestock, and LSOS Study Group.
• Horten Centre for Patient Oriented Research and Knowledge Transfer, University of Zurich, Zurich, Switzerland.
• Spine. 2020 Sep 15; 45 (18): 1309-1316.

Study DesignAnalysis of a prospective, multicenter cohort study.ObjectiveThe aim of our study was to compare thresholds of published minimal clinically important differences (MCID) for the three-level EuroQol-5D health survey (EQ-5D-3L) summary index (range -0.53 to 1.00) with our anchor-based estimate and evaluate how useful these thresholds are in determining treatment success in patients undergoing surgery for degenerative lumbar spinal stenosis (DLSS).Summary Of Background DataMCID values for EQ-5D-3L are specific to the underlying disease and only three studies have been published for DLSS patients reporting different values.MethodsPatients of the multicenter Lumbar Stenosis Outcome Study with confirmed DLSS undergoing first-time decompression or fusion surgery with 12-month follow-up were enrolled in this study. To calculate MCID we used the Spinal Stenosis Measure satisfaction subscale as anchor.ResultsFor this study, 364 patients met the inclusion criteria; of these, 196 were very satisfied, 72 moderately satisfied, 43 somewhat satisfied, and 53 unsatisfied 12 months after surgery. The MCID calculation estimated for EQ-5D-3L a value of 0.19. Compared with published MCID values (ranging from 0.30 to 0.52), our estimation is less restrictive.ConclusionsIn patients with LSS undergoing surgery, we estimated an MCID value for EQ-5D-3L summary index of 0.19 with the help of the average change anchor-based method, which we find to be the most suitable method for assessing patient change scores.Level Of Evidence3.

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