• Eur Respir Rev · Jun 2018

    Review

    Personalised medicine in interstitial lung diseases: Number 6 in the Series "Personalised medicine in respiratory diseases" Edited by Renaud Louis and Nicolas Roche.

    • Maria A Kokosi, George A Margaritopoulos, and Athol U Wells.
    • Interstitial Lung Disease Unit, Royal Brompton and Harefield NHS Foundation Trust, London, UK.
    • Eur Respir Rev. 2018 Jun 30; 27 (148).

    AbstractInterstitial lung diseases in general, and idiopathic pulmonary fibrosis in particular, are complex disorders with multiple pathogenetic pathways, various disease behaviour profiles and different responses to treatment, all facets that make personalised medicine a highly attractive concept. Personalised medicine is aimed at describing distinct disease subsets taking into account individual lifestyle, environmental exposures, genetic profiles and molecular pathways. The cornerstone of personalised medicine is the identification of biomarkers that can be used to inform diagnosis, prognosis and treatment stratification. At present, no data exist validating a personalised approach in individual diseases. However, the importance of the goal amply justifies the characterisation of genotype and pathway signatures with a view to refining prognostic evaluation and trial design, with the ultimate aim of selecting treatments according to profiles in individual patients.Copyright ©ERS 2018.

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