• Intensive care medicine · Jan 1990

    Review

    Mediators of multiple organ failure.

    • R J Goris.
    • Department of General Surgery, University Hospital St. Radboud, Nijmegen, The Netherlands.
    • Intensive Care Med. 1990 Jan 1; 16 Suppl 3 (Suppl 3): S192S196S192-6.

    AbstractMultiple Organ Failure (MOF) has largely been attributed to bacterial sepsis, though conclusive evidence of an essential role for bacteria and/or their endotoxins is still lacking. On the other hand, MOF and the clinical syndrome of sepsis may be aseptically induced in germ-free animals. This paper reviews the evidence that excessive activation of endogenous humoral mediators and inflammatory cells may cause this highly lethal syndrome.

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