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Intensive care medicine · Jan 1997
Case ReportsLiver inflammation and acute respiratory distress syndrome in a patient receiving hepatitis B vaccine: a possible relationship?
- V M Ranieri, A Dell'Erba, A Gentile, F Bruno, V La Gioia, A Spagnolo, R Sacco, G Caruso, S Antonaci, O Schiraldi, and A Brienza.
- Istituto di Medicina Legale, Università di Bari, Ospedale Policlinico, Italy.
- Intensive Care Med. 1997 Jan 1; 23 (1): 119-21.
AbstractWe describe a patient in whom clinical evidence of liver and lung dysfunction developed after he received the second dose of recombinant hepatitis B vaccine, despite no serologic evidence of viral hepatitis. However, liver biopsy specimens demonstrated both surface antigens and core antigens, possibly indicating silent hepatitis B virus infection. A search for an infective etiology for the patient's subsequent clinical deterioration in lung function did not yield pathogens: postmortem examination revealed evidence of immune complex-mediated organ injury in the liver, lungs, and kidneys.
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