• Liam R Maclachlan, Natalie J Collins, Paul W Hodges, and Bill Vicenzino.
• The School of Health and Rehabilitation Sciences, The University of Queensland, St Lucia, Qld, Australia.
• Eur J Pain. 2020 Jul 1; 24 (6): 1182-1196.

BackgroundPatellofemoral pain (PFP) is defined biomechanically, but is characterized by features that fit poorly within nociceptive pain. Mechanisms associated with central sensitization may explain why, for some, symptoms appear nociplastic. This study compares psychological and somatosensory characteristics between those with persistent PFP and controls.MethodsA total of 150 adults with PFP were compared to 61 controls. All participants completed a survey evaluating participant characteristics, PFP-related constructs and psychological factors: anxiety, depression, pain catastrophizing, kinesiophobia, pain self-efficacy. Participants also attended a session of somatosensory testing, which included knee and elbow thermal and mechanical detection and pain thresholds, conditioned pain modulation (CPM), and temporal summation of pain (TSP). Differences were evaluated using analysis of covariance (sex as covariate). Multivariate backward stepwise linear regression examined how psychological and somatosensory variables relate to PFP (knee injury and osteoarthritis outcome score-patellofemoral [KOOS-PF]).ResultsThe PFP group had multimodal reduced pain thresholds at the knee and elbow (standardized mean difference [SMD], p: 0.86-1.2, <.001), reduced mechanical detection at the elbow (0.43, .01) and higher TSP (0.41, .01). CPM was not different. Psychological features demonstrated small effects (0.47-0.59, 0.01-0.04). The PFP group had a 55% (95% CI: 0.47-0.62) risk of kinesiophobia and an 11% (0.06-0.15) reduced pain self-efficacy risk. Kinesiophobia, knee pressure pain threshold, pain self-efficacy and pain catastrophizing explained 40% of KOOS-PF variance (p = <.001).ConclusionsWidespread hyperalgesia and evidence of symptom amplification may reflect nociplastic pain. Clinicians should be aware that kinesiophobia and the nociplastic pain may characterize the condition.Significance(a) Individuals with PFP have widespread reduced pain thresholds to pressure and thermal stimuli. (b) Mechanically induced pain is likely amplified in those with PFP. (c) Pain-related fear is highly prevalent and helps explain PFP-related disability.© 2020 European Pain Federation - EFIC®.

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