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Chem. Biol. Interact. · Mar 2019
ReviewThe linear No-Threshold (LNT) dose response model: A comprehensive assessment of its historical and scientific foundations.
- Edward J Calabrese.
- Department of Environmental Health Sciences, Morrill I, N344, University of Massachusetts, Amherst, MA, 01003, USA. Electronic address: edwardc@schoolph.umass.edu.
- Chem. Biol. Interact. 2019 Mar 1; 301: 6-25.
AbstractThe linear no-threshold (LNT) single-hit (SH) dose response model for cancer risk assessment is comprehensively assessed with respect to its historical foundations. This paper also examines how mistakes, ideological biases, and scientific misconduct by key scientists affected the acceptance, validity, and applications of the LNT model for cancer risk assessment. In addition, the analysis demonstrates that the LNT single-hit model was inappropriately adopted for governmental risk assessment, regulatory policy, practices, and for risk communication.Copyright © 2018 Elsevier B.V. All rights reserved.
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