• Jun-feng Wang, Zhi Guo, Liang Tang, Jian-sheng Guo, Jun Hu, and Jian-zhong Liu.
• Tianjin Medical University Cancer Hospital, Tianjin, China.
• Zhonghua Yi Xue Za Zhi. 2013 Mar 26; 93 (12): 906-9.

ObjectiveTo explore the associations of preoperative plasma levels of fibrinogen and D-dimer with clinicopathologic parameters and overall survival in colorectal cancer patients after curative resection.MethodsFrom January 2002 to December 2003, a total of 341 colorectal cancer patients underwent curative resection. And their relevant clinical data were reviewed. The median age was 58 years (range: 23 - 90 years) and the median follow-up period was 64 months (range: 5 - 89 months). The preoperative plasma levels of fibrinogen and D-dimer were examined, the correlation of clinicopathologic findings and overall survival was analyzed. A Log-rank test was used for univariate analysis and a Cox regression model for multivariate analysis.ResultsThe preoperative plasma levels of fibrinogen and D-dimer were (3.7 ± 0.7) g/L and (0.49 ± 0.18) mg/L respectively. Elevated plasma levels of fibrinogen were associated with advanced tumor stage (P = 0.008), venous invasion (P = 0.006), postoperative distant metastases (P < 0.01) and lymph node involvement (P = 0.001), but not with histologic grade (P = 0.232), and invasion depth (P = 0.253). The overall survival is 64.5% (220/341). Elevated plasma levels of D-dimer were associated with advanced tumor stage (P = 0.013), invasion depth (P = 0.007) and lymph node involvement (P = 0.001), but not with histologic grade (P = 0.082), venous invasion (P = 0.746) or postoperative distant metastases (P = 0.131). Multivariate analysis showed that preoperative plasma levels of fibrinogen (P = 0.029), histologic grade (P = 0.001), and lymph node involvement (P = 0.001) were independent prognostic factors.ConclusionsHigh preoperative plasma levels of fibrinogen and D-dimer are associated with clinicopathologic parameters. And a high preoperative plasma level of fibrinogen is associated with distant metastases and poor prognosis after curative resection in colorectal cancer patients.

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