• Deanna M Arble, Simon S Evers, Nadejda Bozadjieva, Henriette Frikke-Schmidt, Andriy Myronovych, Alfor Lewis, Mouhamadoul Habib Toure, and Randy J Seeley.
• University of Michigan, Department of Surgery, Ann Arbor, Michigan; Marquette University, Department of Biological Sciences, Milwaukee, Wisconsin.
• Surg Obes Relat Dis. 2018 Dec 1; 14 (12): 1857-1867.

BackgroundOne-anastomosis gastric bypass (OAGB) and single-anastomosis duodenal switch (SADS) have become increasingly popular weight loss strategies. However, data directly comparing the effectiveness of these procedures with Roux-en-Y gastric bypass (RYGB) and vertical sleeve gastrectomy (SG) are limited.ObjectivesTo examine the metabolic outcomes of OAGB, SADS, RYGB, and SG in a controlled rodent model.SettingAcademic research laboratory, United States.MethodsSurgeries were performed in diet-induced obese Long-Evans rats, and metabolic outcomes were monitored before and for 15 weeks after surgery.ResultsAll bariatric procedures induced weight loss compared with sham that lasted throughout the course of the study. The highest percent fat loss occurred after OAGB and RYGB. All bariatric procedures had improved glucose dynamics associated with an increase in insulin (notably OAGB and SADS) and/or glucagon-like protein-1 secretion. Circulating cholesterol was reduced in OAGB, SG, and RYGB. OAGB and SG additionally decreased circulating triglycerides. Liver triglycerides were most profoundly reduced after OAGB and RYGB. Circulating iron levels were decreased in all surgical groups, associated with a decreased hematocrit value and increased reticulocyte count. The fecal microbiome communities of OAGB, SADS, and RYGB were significantly altered; however, SG exhibited no change in microbiome diversity or composition.ConclusionsThese data support the use of the rat for modeling bariatric surgical procedures and highlight the ability of the OAGB to meet or exceed the metabolic improvements of RYGB. These data point to the likelihood that each surgery accomplishes metabolic improvements through both overlapping and distinct mechanisms and warrants further research.Copyright © 2018 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

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