• Ketan Yerneni, Noah Nichols, Zachary A Abecassis, Constantine L Karras, and Lee A Tan.
• Department of Neurological Surgery, UCSF Medical Center, San Francisco, California.
• Neurosurgery. 2020 Jun 1; 86 (6): E490-E507.

BackgroundPrescription opioid use and opioid-related deaths have become an epidemic in the United States, leading to devastating economic and health ramifications. Opioids are the most commonly prescribed drug class to treat low back pain, despite the limited body of evidence supporting their efficacy. Furthermore, preoperative opioid use prior to spine surgery has been reported to range from 20% to over 70%, with nearly 20% of this population being opioid dependent.ObjectiveTo review the medical literature on the effect of preoperative opioid use in outcomes in spine surgery.MethodsWe reviewed manuscripts published prior to February 1, 2019, exploring the effect of preoperative opioid use on outcomes in spine surgery. We identified 45 articles that analyzed independently the effect of preoperative opioid use on outcomes (n = 32 lumbar surgery, n = 19 cervical surgery, n = 7 spinal deformity, n = 5 "other").ResultsPreoperative opioid use is overwhelmingly associated with negative surgical and functional outcomes, including postoperative opioid use, hospitalization duration, healthcare costs, risk of surgical revision, and several other negative outcomes.ConclusionThere is an urgent and unmet need to find and apply extensive perioperative solutions to combat opioid use, particularly in patients undergoing spine surgery. Further investigations are necessary to determine the optimal method to treat such patients and to develop opioid-combative strategies in patients undergoing spine surgery.Copyright © 2020 by the Congress of Neurological Surgeons.

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