• Casey M Luckhurst, Majed El Hechi, Ahmed E Elsharkawy, Ahmed I Eid, Lydia R Maurer, Haytham M Kaafarani, Ashraf Thabet, David G Forcione, Carlos Fernández-Del Castillo, Keith D Lillemoe, and Peter J Fagenholz.
• Department of Surgery, Massachusetts General Hospital Boston, MA.
• J. Am. Coll. Surg. 2020 Jun 1; 230 (6): 873-883.

BackgroundA minimally invasive step-up (MIS) approach has been associated with reduced morbidity compared with open surgical necrosectomy (OSN) for treatment of necrotizing pancreatitis. We sought to determine whether transitioning from an OSN to an MIS-based approach would result in reduced mortality. MIS interventions included percutaneous drainage, endoscopic transgastric necrosectomy, video-assisted retroperitoneal debridement, sinus tract endoscopic necrosectomy, or a combination of techniques, with selective use of OSN.Study DesignWe conducted an observational cohort study with retrospective comparison at a single tertiary referral center (2006 through 2019). Eighty-eight patients were treated with OSN and 91 were treated with an MIS-based approach. Baseline characteristics and clinical outcomes were compared between groups. The primary end point was 90-day mortality.ResultsThere was no difference in baseline characteristics. Ninety-day mortality was 2% with MIS compared with 10% with OSN (p = 0.03). One-year mortality was 3% with MIS compared with 15% with OSN (p = 0.012). The rate of organ failure was lower with MIS (30% vs 45%; p = 0.029), but there was a higher bleeding rate (19% vs 9%; p = 0.064). In the MIS group, 9% were treated with percutaneous drainage, 32% with endoscopic transgastric necrosectomy, 8% with video-assisted retroperitoneal debridement, 15% with sinus tract endoscopic necrosectomy, and 27% with a combination of techniques.ConclusionsAdoption of a multidisciplinary MIS-based approach to necrotizing pancreatitis resulted in a 5-fold decrease in mortality compared with OSN.Copyright © 2020 American College of Surgeons. Published by Elsevier Inc. All rights reserved.

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