• Amr S Omar, Hesham Ewila, Sameh Aboulnaga, Alejandro Kohn Tuli, and Rajvir Singh.
• Department of Cardiothoracic Surgery/Cardiac Anaesthesia & ICU Section, Heart Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar; Department of Critical Care Medicine, Beni-Suef University, P.O. Box 62511, Beni-Suef, Egypt.
• Biomed Res Int. 2016 Jan 1; 2016: 7497936.

PurposeRhabdomyolysis (RML) following cardiac surgery and its relationship with acute kidney injury (AKI) require investigation.Patients And MethodsAll patients undergoing cardiac surgery in our hospital were enrolled in this prospective study during a 1-year period. To investigate the occurrence of RML and its association with AKI, all patients in the study underwent serial assessment of serum creatine kinase (CK) and myoglobin levels. Serial renal function, prior statin treatment, and outcome variables were recorded.ResultsIn total, 201 patients were included in the study: 185 men and 16 women with a mean age of 52.0 ± 12.4 years. According to the presence of RML (CK of ≥2,500 U/L), the patients were divided into Group I (RML present in 17 patients) and Group II (RML absent in 184 patients). Seven patients in Group I had AKI (41%) where 34 patients in group II had AKI (18.4%), P = 0.025. We observed a significantly longer duration of ventilation, length of stay in the ICU, and hospitalization in Group I (P < 0.001 for all observations).ConclusionsAn early elevation of serum CK above 2500 U/L postoperatively in high-risk cardiac surgery could be used to diagnose RML that may predict the concomitance of early AKI.

19 keywords...

hide…