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Expert Rev Neurother · Jul 2013
ReviewNeurotrophins, inflammation and oxidative stress as illness activity biomarkers in bipolar disorder.
- Bianca Pfaffenseller, Gabriel R Fries, Bianca Wollenhaupt-Aguiar, Gabriela D Colpo, Laura Stertz, Bruna Panizzutti, Pedro V S Magalhães, and Flávio Kapczinski.
- Laboratório de Psiquiatria Molecular, Instituto Nacional de Ciência e Tecnologia - Translacional em Medicina, Hospital de Clínicas de Porto Alegre, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
- Expert Rev Neurother. 2013 Jul 1; 13 (7): 827-42.
AbstractRecent studies highlight the presence of systemic toxicity as an integral dimension of bipolar disorder pathophysiology, possibly linking this mood disorder with other medical conditions and comorbidities. This review summarizes recent findings on possible peripheral biomarkers of illness activity, with a focus on neurotrophins, inflammation and oxidative stress. The possible mechanisms underlying the systemic toxicity associated with acute episodes in bipolar disorder are also discussed. Finally, the authors outline novel therapies that emerge from this new research and the assessment of multiple biomarkers as a potential approach to improving management strategies in bipolar disorder.
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