• Sci China Life Sci · Apr 2016

    Review

    Establishing guidelines for CAR-T cells: challenges and considerations.

    • Wei Wang, Di-Yuan Qin, Bing-Lan Zhang, Wei Wei, Yong-Sheng Wang, and Yu-Quan Wei.
    • State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China. weiwang@scu.edu.cn.
    • Sci China Life Sci. 2016 Apr 1; 59 (4): 333-9.

    AbstractT cells, genetically modified by chimeric antigen receptors (CAR-T), are endowed with specificity to a desired antigen and are cytotoxic to cells expressing the targeted antigen. CAR-T-based cancer immunotherapy is a promising therapy for curing hematological malignancy, such as acute lymphoid leukemia, and is promising for extending their efficacy to defeat solid tumors. To date, dozens of different CAR-T cells have been evaluated in clinical trials to treat tumors; this necessitates the establishment of guidelines for the production and application of CAR-T cells. However, it is challenging to standardize CAR-T cancer therapy because it involves a combination of gene therapy and cell therapy. In this review, we compare the existing guidelines for CAR-T cells and discuss the challenges and considerations for establishing guidance for CAR-T-based cancer immunotherapy.

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