• Hiroaki Shiba, Yuichi Ishida, Shigeki Wakiyama, Tomonori Iida, Michinori Matsumoto, Taro Sakamoto, Ryusuke Ito, Takeshi Gocho, Kenei Furukawa, Yuki Fujiwara, Shoichi Hirohara, Takeyuki Misawa, and Katsuhiko Yanaga.
• Department of Surgery, Jikei University School of Medicine, Tokyo, Japan. hs0817@jikei.ac.jp
• J. Gastrointest. Surg. 2009 Sep 1; 13 (9): 1636-42.

BackgroundIn perioperative management of hepatic resection for hepatocellular carcinoma, excessive blood loss and blood transfusion greatly influence postoperative complications and prognosis of the patients. We evaluated the influence of blood products use on postoperative recurrence and prognosis of patients with hepatocellular carcinoma.MethodsThe subjects were 66 patients who underwent elective hepatic resection for hepatocellular carcinoma without concomitant microwave or radiofrequency ablation therapy nor other malignancies between January 2001 and June 2006. We retrospectively investigated the influence of the use of blood products including red cell concentration and fresh frozen plasma on recurrence of hepatocellular carcinoma and overall survival.ResultsIn multivariate analysis, the dose of blood products transfusion was a significant predictor of disease-free and overall survival. Both disease-free and overall survival rates of those who were given blood products were significantly worse than those who did not receive. On the other hand, in univariate analysis of disease-free and overall survival after hepatic resection and clinical variables, the amount of blood loss was not a significant predictor of recurrence or death.ConclusionTransfusion of blood products is associated with increased recurrence rate and worse survival after elective hepatic resection for patients with hepatocellular carcinoma.

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