• Pan Luo, Zhencheng Xiong, Wei Sun, Lijun Shi, Fuqiang Gao, and Zirong Li.
• Peking Union Medical College, Chinese Academy of Medical Sciences, Graduate School of Peking Union Medical College, Department of Orthopedics, China-Japan Friendship Hospital, China-Japan Friendship Institute of Clinical Medicine, Beijing 100029, China.
• Pain Res Manag. 2020 Jan 1; 2020: 75879367587936.

ObjectiveThe purpose of this meta-analysis was to determine whether platelet-rich plasma (PRP) was better than hyaluronic acid (HA) for the treatment of knee osteoarthritis (OA) in overweight or obese patients.DesignTwo reviewers independently used the keywords combined with free words to search English-based electronic databases according to Cochrane Collaboration guidelines, such as PubMed, Embase, ScienceDirect, and Cochrane library. The pooled data were analyzed using RevMan 5.3.ResultsTen randomized controlled trials (RCTs) with 1096 patients were included. During the first two months of follow-up, there was no significant difference between the two groups. At the 3rd, 6th, and 12th months of follow-up, the pooled analysis showed that PRP was better than HA for the treatment of knee OA in overweight or obese patients. There were significant differences between the two groups at Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) total score (3 months: MD = -1.35, [95% CI: -2.19 to -0.50], P=0.002, I 2 = 0%; 6 months: MD = -7.62, [95% CI: -13.51 to -1.72], P=0.01, I 2 = 88%; 12 months: MD = -12.11, [95% CI: -20.21 to -4.01], P=0.003, I 2 = 94%).ConclusionsFor overweight or obese patients with knee OA, intra-articular injection of PRP in a short time was not necessarily superior to HA, but long-term use was better than HA in pain and functional relief.Copyright © 2020 Pan Luo et al.

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