• Safiya Richardson, Jamie S Hirsch, Mangala Narasimhan, James M Crawford, Thomas McGinn, Karina W Davidson, the Northwell COVID-19 Research Consortium, Douglas P Barnaby, Lance B Becker, John D Chelico, Stuart L Cohen, Jennifer Cookingham, Kevin Coppa, Michael A Diefenbach, Andrew J Dominello, Joan Duer-Hefele, Louise Falzon, Jordan Gitlin, Negin Hajizadeh, Tiffany G Harvin, David A Hirschwerk, Eun Ji Kim, Zachary M Kozel, Lyndonna M Marrast, Jazmin N Mogavero, Gabrielle A Osorio, Michael Qiu, and Theodoros P Zanos.
• Institute of Health Innovations and Outcomes Research, Feinstein Institutes for Medical Research, Northwell Health, Manhasset, New York.
• JAMA. 2020 May 26; 323 (20): 2052-2059.

ImportanceThere is limited information describing the presenting characteristics and outcomes of US patients requiring hospitalization for coronavirus disease 2019 (COVID-19).ObjectiveTo describe the clinical characteristics and outcomes of patients with COVID-19 hospitalized in a US health care system.Design, Setting, And ParticipantsCase series of patients with COVID-19 admitted to 12 hospitals in New York City, Long Island, and Westchester County, New York, within the Northwell Health system. The study included all sequentially hospitalized patients between March 1, 2020, and April 4, 2020, inclusive of these dates.ExposuresConfirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection by positive result on polymerase chain reaction testing of a nasopharyngeal sample among patients requiring admission.Main Outcomes And MeasuresClinical outcomes during hospitalization, such as invasive mechanical ventilation, kidney replacement therapy, and death. Demographics, baseline comorbidities, presenting vital signs, and test results were also collected.ResultsA total of 5700 patients were included (median age, 63 years [interquartile range {IQR}, 52-75; range, 0-107 years]; 39.7% female). The most common comorbidities were hypertension (3026; 56.6%), obesity (1737; 41.7%), and diabetes (1808; 33.8%). At triage, 30.7% of patients were febrile, 17.3% had a respiratory rate greater than 24 breaths/min, and 27.8% received supplemental oxygen. The rate of respiratory virus co-infection was 2.1%. Outcomes were assessed for 2634 patients who were discharged or had died at the study end point. During hospitalization, 373 patients (14.2%) (median age, 68 years [IQR, 56-78]; 33.5% female) were treated in the intensive care unit care, 320 (12.2%) received invasive mechanical ventilation, 81 (3.2%) were treated with kidney replacement therapy, and 553 (21%) died. As of April 4, 2020, for patients requiring mechanical ventilation (n = 1151, 20.2%), 38 (3.3%) were discharged alive, 282 (24.5%) died, and 831 (72.2%) remained in hospital. The median postdischarge follow-up time was 4.4 days (IQR, 2.2-9.3). A total of 45 patients (2.2%) were readmitted during the study period. The median time to readmission was 3 days (IQR, 1.0-4.5) for readmitted patients. Among the 3066 patients who remained hospitalized at the final study follow-up date (median age, 65 years [IQR, 54-75]), the median follow-up at time of censoring was 4.5 days (IQR, 2.4-8.1).Conclusions And RelevanceThis case series provides characteristics and early outcomes of sequentially hospitalized patients with confirmed COVID-19 in the New York City area.

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