• M Torres-Ferrús, F Ursitti, A Alpuente, F Brunello, D Chiappino, T de Vries, S Di Marco, S Ferlisi, L Guerritore, N Gonzalez-Garcia, A Gonzalez-Martinez, D Khutorov, M Kritsilis, A Kyrou, T Makeeva, A Minguez-Olaondo, L Pilati, A Serrien, O Tsurkalenko, D Van den Abbeele, W S van Hoogstraten, C Lampl, and School of Advanced Studies of European Headache Federation (EHF-SAS).
• Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain. marttorr@vhebron.net.
• J Headache Pain. 2020 Apr 29; 21 (1): 4242.

AbstractChronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.

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