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J Neuropsychiatry Clin Neurosci · Jan 2007
Mood-elevating effects of opioid analgesics in patients with bipolar disorder.
- Charles B Schaffer, Thomas E Nordahl, Linda C Schaffer, and Jeanne Howe.
- Department of Psychiatry and Behavioral Sciences, University of California, Davis, California, USA. schafferpsych@sbcglobal.net
- J Neuropsychiatry Clin Neurosci. 2007 Jan 1; 19 (4): 449-52.
AbstractOpioids can have mood-elevating effects in healthy subjects and have been used successfully to treat refractory depressed patients. A few case reports indicate that opioid analgesics can induce mania. The authors investigated the mood reaction of opioid analgesics in patients with bipolar disorder. Nine (27%) of 33 patients who took opioid analgesics for medical reasons experienced a significant hypomanic/manic reaction, and two other patients reported an antidepressant effect. None of the comparison subjects reported a significant mood reaction from opioid analgesics. These results indicate that opioid analgesics can have an important mood-altering effect on patients with known bipolar disorder.
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