• Adriano Nunes Kochi, Ana Paula Tagliari, Giovanni Battista Forleo, Gaetano Michele Fassini, and Claudio Tondo.
• Heart Rhythm Center, Centro Cardiologico Monzino IRCCS, Milan, Italy.
• J. Cardiovasc. Electrophysiol. 2020 May 1; 31 (5): 1003-1008.

AbstractIn December 2019, the world started to face a new pandemic situation, the severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2). Although coronavirus disease (COVID-19) clinical manifestations are mainly respiratory, major cardiac complications are being reported. Cardiac manifestations etiology seems to be multifactorial, comprising direct viral myocardial damage, hypoxia, hypotension, enhanced inflammatory status, ACE2-receptors downregulation, drug toxicity, endogenous catecholamine adrenergic status, among others. Studies evaluating patients with COVID-19 presenting cardiac injury markers show that it is associated with poorer outcomes, and arrhythmic events are not uncommon. Besides, drugs currently used to treat the COVID-19 are known to prolong the QT interval and can have a proarrhythmic propensity. This review focus on COVID-19 cardiac and arrhythmic manifestations and, in parallel, makes an appraisal of other virus epidemics as SARS-CoV, Middle East respiratory syndrome coronavirus, and H1N1 influenza.© 2020 Wiley Periodicals, Inc.

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