• Xingwang Zhou, XiaoDong Niu, Kaijun Sun, Junhong Li, Qing Mao, and Yanhui Liu.
• Department of Neurosurgery, West China Hospital, Chengdu, Sichuan Province, P. R. China.
• World Neurosurg. 2020 Jul 1; 139: e700-e707.

ObjectiveTo assess the early mortality in pediatric glioma and identify predictors of early mortality, which may provide insight into the therapeutic strategies for children with a high risk of early mortality.MethodsWe used SEER∗Stat 8.3.5 software to extract data of pediatric glioma from the Surveillance, Epidemiology, and End Results database. Logistical regression to identify the independent factors in predicting early mortality.ResultsA total of 3035 male and 2741 female patients were enrolled in the present study. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Early mortality decreased significantly during the past 40 years. Our results showed that glioblastoma, anaplastic glioma, and oligodendroglioma were risk factors of early mortality for children diagnosed with glioma, whereas advanced age, gross total resection, radiation, and chemotherapy were associated with decreased early mortality.ConclusionsWe found a decrease in early mortality during the past 40 years. The death rates within 1 month and 3 months after diagnosis were 1.32% and 2.44%, respectively. Age at diagnosis, histologic subtype, the extent of resection, chemotherapy, and radiation were associated with early mortality in pediatric glioma.Copyright © 2020 Elsevier Inc. All rights reserved.

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