• Hepato Gastroenterol · Jan 2003

    Thrombopoietin levels and peripheral platelet counts following living related donor liver transplantation.

    • Akihiro Tsukahara, Yoshinobu Sato, Satoshi Yamamoto, Susumu Suzuki, Hideki Nakatsuka, Takaoki Watanabe, Hitoshi Kameyama, and Katsuyoshi Hatakeyama.
    • First Department of Surgery, Niigata University School of Medicine, 1-757 Asahimachi-dori, Niigata, 951-8510, Japan.
    • Hepato Gastroenterol. 2003 Jan 1; 50 (49): 227-30.

    Background/AimsThrombopoietin is the primary hematopoietic growth factor. Thrombopoietin deficiency may cause thrombocytopenia in advanced liver disease. The aim of our study was to investigate the relevance of thrombopoietin levels to peripheral platelet counts in patients with liver disease who underwent LRDLT (living related donor liver transplantation).MethodologyWe divided the six patients who underwent LRDLT into two groups. Group 1 had thrombocytopenia and group 2 had normal platelet counts. We measured serum thrombopoietin and peripheral platelet counts before and after LRDLT.ResultsPre-LRDLT thrombopoietin and peripheral platelet counts were lower in group 1 than in group 2. Thrombopoietin in group 1 significantly increased on the first day after LRDLT and peripheral platelet counts in group 1 increased following the rise in thrombopoietin (p < 0.05). Moreover, a marked increase in thrombopoietin and peripheral platelet counts was found in splenectomized patients during LRDLT.ConclusionsThese findings suggested inadequate thrombopoietin production in advanced stage liver disease which caused thrombocytopenia. Improvement of thrombopoietin production in graft liver function may contribute to increase of peripheral platelet counts.

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