• Joao Seda Neto, Eduardo A Fonseca, Flávia H Feier, Renata Pugliese, Helry L Candido, Marcel R Benavides, Gilda Porta, Irene K Miura, Vera B Danesi, Teresa Guimaraes, Adriana Porta, Cristian Borges, Andre Godoy, Mario Kondo, and Paulo Chapchap.
• Hepatology and Liver Transplantation, Hospital Sirio-Libanes, São Paulo, Brazil; A. C. Camargo Cancer Center, São Paulo, Brazil.
• Liver Transpl. 2014 Oct 1; 20 (10): 1157-67.

AbstractThe technique of vascular reconstruction plays a major role in the outcome of living donor liver transplantation (LDLT). An increased use of vascular grafts (VGs) as replacements for sclerotic portal veins has become a standard technique for our group. The aim of this study was to analyze the factors associated with portal vein thrombosis (PVT) in pediatric LDLT. We performed a retrospective analysis of 486 primary pediatric LDLT procedures performed between October 1995 and May 2013. VGs used for portal reconstruction included living donor inferior mesenteric veins, living donor ovarian veins, recipient internal jugular veins, deceased donor iliac arteries, and deceased donor iliac veins. Thirty-four patients (7.0%) developed PVT. The incidence of PVT dropped from 10.1% to 2%; the overall utilization of VGs increased from 3.5% to 37.1%. In a multivariate analysis, only the use of VGs remained an independent risk factor for the occurrence of PVT (hazard ratio = 7.2, 95% confidence interval = 2.8-18.7, P < 0.001). There was no difference in survival rates between patients with PVT and patients without PVT. No patient with PVT underwent retransplantation. In conclusion, the use of VGs was independently associated with the development of PVT. Over time, there was a reduction in the incidence of early PVT in this cohort, and there was a trend toward a reduction in total PVT. The occurrence of isolated PVT in this study was not associated with decreased patient or graft survival.© 2014 American Association for the Study of Liver Diseases.

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