• Sheraz R Markar, Giovanni Zaninotto, Carlo Castoro, Asif Johar, Pernilla Lagergren, Jessie A Elliott, Suzanne S Gisbertz, Christophe Mariette, Rita Alfieri, Jeremy Huddy, Viknesh Sounderajah, Eleonora Pinto, Marco Scarpa, Fredrik Klevebro, Berit Sunde, Conor F Murphy, Christine Greene, Narayanasamy Ravi, Guillaume Piessen, Hylke Brenkman, Jelle P Ruurda, Richard Van Hillegersberg, Sjoerd Lagarde, Bas Wijnhoven, Manuel Pera, José Roig, Sandra Castro, Robert Matthijsen, John Findlay, Stefan Antonowicz, Nick Maynard, Orla McCormack, Arun Ariyarathenam, Grant Sanders, Edward Cheong, Shameen Jaunoo, William Allum, Jan Van Lanschot, Magnus Nilsson, John V Reynolds, Mark I van Berge Henegouwen, and George B Hanna.
• Department Surgery and Cancer, Imperial College London, UK.
• Ann. Surg. 2022 Feb 1; 275 (2): e392-e400.

ObjectiveTo identify the most prevalent symptoms and those with greatest impact upon health-related quality of life (HRQOL) among esophageal cancer survivors.BackgroundLong-term symptom burden after esophagectomy, and associations with HRQOL, are poorly understood.Patients And MethodsBetween 2010 and 2016, patients from 20 European Centers who underwent esophageal cancer surgery, and were disease-free at least 1 year postoperatively were asked to complete LASER, EORTC-QLQ-C30, and QLQ-OG25 questionnaires. Specific symptom questionnaire items that were associated with poor HRQOL as identified by EORTC QLQ-C30 and QLQ-OG25 were identified by multivariable regression analysis and combined to form a tool.ResultsA total of 876 of 1081 invited patients responded to the questionnaire, giving a response rate of 81%. Of these, 66.9% stated in the last 6 months they had symptoms associated with their esophagectomy. Ongoing weight loss was reported by 10.4% of patients, and only 13.8% returned to work with the same activities.Three LASER symptoms were correlated with poor HRQOL on multivariable analysis; pain on scars on chest (odds ratio (OR) 1.27; 95% CI 0.97-1.65), low mood (OR 1.42; 95% CI 1.15-1.77) and reduced energy or activity tolerance (OR 1.37; 95% CI 1.18-1.59). The areas under the curves for the development and validation datasets were 0.81 ± 0.02 and 0.82 ± 0.09 respectively.ConclusionTwo-thirds of patients experience significant symptoms more than 1 year after surgery. The 3 key symptoms associated with poor HRQOL identified in this study should be further validated, and could be used in clinical practice to identify patients who require increased support.Copyright © 2020 Wolters Kluwer Health, Inc. All rights reserved.

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