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Palliative medicine · Mar 2013
Review Case ReportsProgressive multifocal leukoencephalopathy and palliative care: a report of three cases and review of the literature.
- Penelope Janet Helen Cotton and Brian Le.
- Royal Melbourne Hospital, Department of Palliative Care, Australia. penine@gmail.com
- Palliat Med. 2013 Mar 1;27(3):286-8.
AbstractProgressive multifocal leukoencephalopathy (PML) is a rare but usually fatal demyelinating disease of the central nervous system in patients who are immunocompromised. It is characterized by rapid neurological deterioration associated with progressive white matter changes on imaging and is confirmed by isolation of the causative virus in the cerebrospinal fluid or brain tissue. Currently there are no effective treatments for PML and outcomes remain poor even after reversal of the immunocompromised state. This case series describes three patients with different underlying pathologies and varying presentations who were all diagnosed with PML and referred to a palliative care service.
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