• Tyler W Buckner, Katharine Batt, Doris Quon, Michelle Witkop, Michael Recht, Craig Kessler, Kimberly Baumann, Grace Hernandez, Michael Wang, David L Cooper, and Christine L Kempton.
• University of Colorado School of Medicine, Aurora, CO, USA.
• Eur. J. Haematol. 2018 Apr 1; 100 Suppl 1: 5-13.

IntroductionPain, functional impairment, anxiety, and depression associated with joint disease may affect health-related quality of life (HRQoL) in people with hemophilia.ObjectiveTo report detailed patient-reported outcomes (PRO) assessments related to HRQoL in participants in the Pain, Functional Impairment, and Quality of Life (P-FiQ) study.MethodsPain and HRQoL were assessed via PRO instruments in US adult males with hemophilia A or B and a history of joint pain or bleeding. PRO instruments included EQ-5D-5L with visual analog scale, Brief Pain Inventory v2 Short Form, SF-36v2, and Hemophilia Activities List. Instrument domain and item responses were described.ResultsResponses were collected from 381 adult males with a median age of 34 years. Pain was observed across instruments and affected daily activities and quality of life. Respondents reported functional impairment that limited the kind of work and activities they participated in, with activities involving the lower extremities being most affected. A high prevalence of mental health disorders was identified across instruments.ConclusionsPain and HRQoL were evaluated using multiple PRO instruments, which vary in timescales of assessment and levels of detail. More consistent clinical assessments and patient dialog regarding pain and aspects of HRQoL may help drive improved outcomes.© 2018 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

26 keywords...

hide…