• K Markstaller, H U Kauczor, B Eberle, N Weiler, D Siebertz, K Birkenkamp, W Heinrichs, and M Thelen.
• Klinik und Poliklinik für Radiologie, Johannes Gutenberg-Universität Mainz. Klm@mail.uni-mainz.de
• Rofo. 1999 Jun 1; 170 (6): 575-80.

PurposeIn this animal study, density ranges for CT-based quantification of ventilated lung area were determined. Healthy lungs and ARDS lungs were compared during artificial respiration.Material And MethodsCT-scans were performed in 5 anesthetized pigs using a dynamic multiscan CT option on a predefined transverse slice (slice thickness 1 mm; effective temporal resolution, 250 ms). During continuous CT acquisition, airway pressure was increased or decreased in a stepwise manner. In all images, areas of defined HU ranges were determined planimetrically. The lower threshold was set to -910 HE in all images. The upper threshold was varied from -800 HE to -200 HE in steps of 100 HE.ResultsDuring inspiration in healthy lungs the HU-range of -910 to -700 HU showed the largest increase in area. During inspiration in ARDS lungs the HU range from -910 to -300 HU allowed the most sensitive assessment of area changes. These findings can be explained by recruitment of atelectases (HU-range > -300 HU) and their transition to a HU range from -700 to -300 HU.ConclusionDynamic multiscan CT acquisitions are a useful method to determine changes of ventilated lung area during a respiratory cycle. Different HU-ranges are required to access volume changes in healthy lungs and in ARDS lungs.

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