• Anasthesiol Intensivmed Notfallmed Schmerzther · May 2020

    [Drug-drug Interactions in Intensive Care].

    • Andreas Drust.
    • Anasthesiol Intensivmed Notfallmed Schmerzther. 2020 May 1; 55 (5): 300-313.

    AbstractDrug-drug interactions are common problems in intensive care units. Numerous studies could demonstrate the impact of the total amount of prescribed drugs and the occurrence of potential respectively manifest drug-drug interactions in critically ill patients. The average number of clinically used drugs in this setting is approximately 25 - 35 per patient, thus the profound knowledge of pharmacodynamic and pharmakokinetic mechanisms regarding drug interplay is important for treatment safety. This review aims to summarize the current evidence of drug interactions in intensive care patients. It especially features data regarding pharmacokinetics as main reason for clinically relevant drug-drug interactions. The most important drug classes noted in this context are analgesics and sedatives, antibiotics, antimycotics, antiepileptics, immune suppressive drugs, prokinetics and gastric acid regulating drugs. Furthermore, some pharmacodynamic interactions are described like QTc prolongation or serotonin syndrome. Additionally, a clinical case is demonstrated regarding the malignant impact of rifampin co-medication in a patient suffering from severe hypertension with the use of several antihypertensive drugs.Georg Thieme Verlag KG Stuttgart · New York.

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