Duration of pre-operative fasting in children is associated with increased risk of post-induction hypotension.

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• Allan F Simpao, Lezhou Wu, Olivia Nelson, Jorge A Gálvez, Jonathan M Tan, Jack O Wasey, Wallis T Muhly, Fu-Chiang Tsui, Aaron J Masino, and Paul A Stricker.
• From the Departments of Anesthesiology and Critical Care Medicine (A.F.S., L.W., O.N., J.A.G., J.M.T., J.O.W., W.T.M., F.-C.T., A.J.M., P.A.S.) Biomedical and Health Informatics (A.F.S., L.W., J.A.G., J.M.T., J.O.W., F.-C.T., A.J.M.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania the Department of Anesthesiology and Critical Care, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania (A.F.S., J.A.G., J.M.T., J.O.W., W.T.M., F.-C.T., A.J.M., P.A.S.).
• Anesthesiology. 2020 Sep 1; 133 (3): 523-533.

BackgroundChildren are required to fast before elective general anesthesia. This study hypothesized that prolonged fasting causes volume depletion that manifests as low blood pressure. This study aimed to assess the association between fluid fasting duration and postinduction low blood pressure.MethodsA retrospective cohort study was performed of 15,543 anesthetized children without preinduction venous access who underwent elective surgery from 2016 to 2017 at Children's Hospital of Philadelphia. Low blood pressure was defined as systolic blood pressure lower than 2 standard deviations below the mean (approximately the 2.5th percentile) for sex- and age-specific reference values. Two epochs were assessed: epoch 1 was from induction to completion of anesthesia preparation, and epoch 2 was during surgical preparation.ResultsIn epoch 1, the incidence of low systolic blood pressure was 5.2% (697 of 13,497), and no association was observed with the fluid fasting time groups: less than 4 h (4.6%, 141 of 3,081), 4 to 8 h (6.0%, 219 of 3,652), 8 to 12 h (4.9%, 124 of 2,526), and more than 12 h (5.0%, 213 of 4,238). In epoch 2, the incidence of low systolic blood pressure was 6.9% (889 of 12,917) and varied across the fasting groups: less than 4 h (5.6%, 162 of 2,918), 4 to 8 h (8.1%, 285 of 3,531), 8 to 12 h (5.9%, 143 of 2,423), and more than 12 h (7.4%, 299 of 4,045); after adjusting for confounders, fasting 4 to 8 h (adjusted odds ratio, 1.33; 95% CI, 1.07 to 1.64; P = 0.009) and greater than 12 h (adjusted odds ratio, 1.28; 95% CI, 1.04 to 1.57; P = 0.018) were associated with significantly higher odds of low systolic blood pressure compared with the group who fasted less than 4 h, whereas the increased odds of low systolic blood pressure associated with fasting 8 to 12 h (adjusted odds ratio, 1.11; 95% CI, 0.87 to 1.42; P = 0.391) was nonsignificant.ConclusionsLonger durations of clear fluid fasting in anesthetized children were associated with increased risk of postinduction low blood pressure during surgical preparation, although this association appeared nonlinear.

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