• Servan Gökhan, İsmail Erkan Aydın, Pamukçu Günaydın Gül G Department of Emergency Medicine, Yıldırım Beyazıt University Faculty of Medicine, Ankara-Turkey., Çağdaş Yıldırım, Fatih Tanrıverdi, Selahattin Gürü, Fatih Ahmet Kahraman, and Ozcan Erel.
• Department of Emergency Medicine, Yıldırım Beyazıt University Faculty of Medicine, Ankara-Turkey.
• Ulus Travma Acil Cer. 2020 May 1; 26 (3): 389-395.

BackgroundThis study aims to investigate the role of thiol/disulfide homeostasis parameters in the diagnosis of acute appendicitis and to determine whether it is beneficial to use these parameters in combination with the modified Alvarado and RIPASA scoring systems.MethodsThis study was prospectively carried out on 265 patients who presented to the emergency department with the complaint of right lower quadrant pain between 01.07.2017 and 31.12.2017, and met the inclusion criteria of this study. Oxidative stress markers were evaluated on two groups. The relationship between these parameters and the modified Alvarado and RIPASA scoring systems was analyzed.ResultsThe mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were found to be significantly higher in the appendicitis group (p<0.001). The mean levels of native thiol, total thiol and native thiol/total thiol were significantly lower in the same group (p<0.001, 0.001 and 0.007, respectively). The mean levels of disulfide, disulfide/native thiol and disulfide/total thiol were recorded to be significantly higher in the high-risk group according to the results of RIPASA (p=0.016, 0.003 and 0.001, respectively).ConclusionThiol/disulfide homeostasis parameters can be used with the modified Alvarado and RIPASA scoring systems in the diagnosis of acute appendicitis.

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