• Fabio Parazzini, Renata Bortolus, Paola Agnese Mauri, Alessandro Favilli, Sandro Gerli, and Enrico Ferrazzi.
• Department of Obstetrics and Gynecology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
• Int J Gynaecol Obstet. 2020 Jul 1; 150 (1): 41-46.

BackgroundFew case reports and clinical series exist on pregnant women infected with SARS-CoV-2 who delivered.ObjectiveTo review the available information on mode of delivery, vertical/peripartum transmission, and neonatal outcome in pregnant women infected with SARS-CoV-2.Search StrategyCombination of the following key words: COVID-19, SARS-CoV-2, and pregnancy in Embase and PubMed databases.Selection CriteriaPapers reporting cases of women infected with SARS-CoV-2 who delivered.Data Collection And AnalysisThe following was extracted: author; country; number of women; study design; gestational age at delivery; selected clinical maternal data; mode of delivery; selected neonatal outcomes.Main ResultsIn the 13 studies included, vaginal delivery was reported in 6 cases (9.4%; 95% CI, 3.5-19.3). Indication for cesarean delivery was worsening of maternal conditions in 31 cases (48.4%; 95% CI, 35.8-61.3). Two newborns testing positive for SARS-CoV-2 by real-time RT-PCR assay were reported. In three neonates, SARS-CoV-2 IgG and IgM levels were elevated but the RT-PCR test was negative.ConclusionsThe rate of vertical or peripartum transmission of SARS-CoV-2 is low, if any, for cesarean delivery; no data are available for vaginal delivery. Low frequency of spontaneous preterm birth and general favorable immediate neonatal outcome are reassuring.© 2020 International Federation of Gynecology and Obstetrics.

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