• M-A S Y Wright, M Orth, P N Patsalos, S J M Smith, and M P Richardson.
• Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK.
• Neurology. 2006 Nov 14; 67 (9): 1646-51.

ObjectiveTo test the hypothesis that cortical excitability changes prior to seizures, using transcranial magnetic brain stimulation (TMS).MethodsWe studied 18 patients with unilateral temporal lobe epilepsy (TLE) twice using TMS: prior to (day 1) and following (day 3) reduction of antiepileptic drugs in a monitored inpatient setting. Short-latency intracortical inhibition (SICI) and intracortical facilitation (ICF) were measured. Time since most recent seizure prior to day 1, and time until next seizure after day 3, were recorded.ResultsOn day 1, prior to antiepileptic drug withdrawal, there were no correlations with recent or next seizures. On day 3, patients who had seizures in the subsequent 48 hours had weaker SICI and ICF in the hemisphere ipsilateral to seizure onset, vs patients who did not have seizures in the next 48 hours (p = 0.033). Additionally on day 3, there was a strong correlation between the difference between ICF and SICI in the ipsilateral hemisphere and time to next seizure (p < 0.001).ConclusionsChange in cortical excitability, measured with transcranial magnetic brain stimulation, may reflect a long-lasting and widespread pre-ictal state.

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