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- G G Lockwood, S M Sapsed-Byrne, and M A Smith.
- Department of Anaesthesia, Hammersmith Hospital, London.
- Br J Anaesth. 1997 Oct 1; 79 (4): 517-20.
AbstractWe have investigated the effect of temperature on the blood-gas solubility of desflurane, sevoflurane, enflurane and halothane. Blood was equilibrated with gas mixtures of known composition in open cuvette or closed flask tonometers over a temperature range of 29-39 degrees C, and the concentration of each anaesthetic in blood was measured at 37 degrees C by repeated headspace analysis using a gas chromatograph. Solubility increased by 5.4% of the solubility at 37 degrees C for each degree that equilibration temperature was reduced. This result was true for all anaesthetics in all blood samples, and is in keeping with results for other volatile anaesthetics.
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