• J. Thromb. Haemost. · Apr 2020

    Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia.

    • Ning Tang, Dengju Li, Xiong Wang, and Ziyong Sun.
    • Department of Clinical Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
    • J. Thromb. Haemost. 2020 Apr 1; 18 (4): 844-847.

    BackgroundIn the recent outbreak of novel coronavirus infection in Wuhan, China, significantly abnormal coagulation parameters in severe novel coronavirus pneumonia (NCP) cases were a concern.ObjectivesTo describe the coagulation feature of patients with NCP.MethodsConventional coagulation results and outcomes of 183 consecutive patients with confirmed NCP in Tongji hospital were retrospectively analyzed.ResultsThe overall mortality was 11.5%, the non-survivors revealed significantly higher D-dimer and fibrin degradation product (FDP) levels, longer prothrombin time and activated partial thromboplastin time compared to survivors on admission (P < .05); 71.4% of non-survivors and 0.6% survivors met the criteria of disseminated intravascular coagulation during their hospital stay.ConclusionsThe present study shows that abnormal coagulation results, especially markedly elevated D-dimer and FDP are common in deaths with NCP.© 2020 International Society on Thrombosis and Haemostasis.

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