• Eur J Case Rep Intern Med · Jan 2020

    Tocilizumab in Severe COVID-19 Pneumonia and Concomitant Cytokine Release Syndrome.

    • Tom DA van Kraaij, Rémy Lm Mostard, Sofia Ramiro, Cesar Magro Checa, Christel Mp van Dongen, Eric Hj van Haren, Jacqueline Buijs, and Robert Bm Landewé.
    • Department of Pulmonology, Zuyderland Medical Center, Heerlen-Sittard, the Netherlands.
    • Eur J Case Rep Intern Med. 2020 Jan 1; 7 (5): 001675.

    AbstractYounger patients with COVID-19 may experience an exaggerated immune response to SARS-CoV-2 infection and develop cytokine release syndrome (CRS), which may be life threatening. There is no proven antiviral therapy for COVID-19 so far, but profound immunosuppression has recently been suggested as a treatment for COVID-19-associated CRS. We present a case of life-threatening CRS caused by COVID-19 infection with a favourable response to immunosuppressive therapy with tocilizumab (TCZ). The rapid clinical and biochemical improvement following TCZ administration suggests that treatment with immunotherapy can be life-saving in selected patients with COVID-19-induced CRS.© EFIM 2020.

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