• A Mechteld Lehr, F Cumhur Oner, Diyar Delawi, Rebecca K Stellato, Eric A Hoebink, Diederik H R Kempen, van SusanteJob L CJLCDepartment of Orthopaedic Surgery, Rijnstate Hospital, Arnhem, The Netherlands., René M Castelein, Moyo C Kruyt, and Dutch Clinical Spine Research Group.
• Department of Orthopaedic Surgery, University Medical Center Utrecht, Utrecht, The Netherlands.
• Spine. 2020 Oct 15; 45 (20): 140314101403-1410.

Study DesignTwo-year clinical and radiographic follow-up of a double-blind, multicenter, randomized, intra-patient controlled, non-inferiority trial comparing a bone graft substitute (AttraX Putty) with autograft in instrumented posterolateral fusion (PLF) surgery.ObjectivesThe aim of this study was to compare PLF rates between 1 and 2 years of follow-up and between graft types, and to explore the role of bone grafting based on the location of the PLF mass.Summary Of Background DataThere are indications that bony fusion proceeds over time, but it is unknown to what extent this can be related to bone grafting.MethodsA total of 100 adult patients underwent a primary, single- or multilevel, thoracolumbar PLF. After instrumentation and preparation for grafting, the randomized allocation side of AttraX Putty was disclosed. The contralateral posterolateral gutters were grafted with autograft. At 1-year follow-up, and in case of no fusion at 2 years, the fusion status of both sides of each segment was blindly assessed on CT scans. Intertransverse and facet fusion were scored separately. Difference in fusion rates after 1 and 2 years and between grafts were analyzed with a Generalized Estimating Equations (GEE) model (P < 0.05).ResultsThe 2-year PLF rate (66 patients) was 70% at the AttraX Putty and 68% at the autograft side, compared to 55% and 52% after 1 year (87 patients). GEE analysis demonstrated a significant increase for both conditions (odds ratio 2.0, 95% confidence interval 1.5-2.7, P < 0.001), but no difference between the grafts (P = 0.595). Ongoing bone formation was only observed between the facet joints.ConclusionThis intra-patient controlled trial demonstrated a significant increase in PLF rate between 1 and 2 years after instrumented thoracolumbar fusion, but no difference between AttraX Putty and autograft. Based on the location of the PLF mass, this increase is most likely the result of immobilization instead of grafting.Level Of Evidence1.

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