• Dtsch. Med. Wochenschr. · Dec 2019

    Historical Article

    [Maurice Raynaud (1834-1881) and the Mystery of "Raynaud's Phanomenon"].

    • Ulrich Koehler, Irene Portig, Olaf Hildebrandt, and Niklas Alexander Koehler.
    • Dtsch. Med. Wochenschr. 2019 Dec 1; 144 (25): 1778-1783.

    AbstractMaurice Raynaud first described color changes and symptoms of the fingers due to cold-induced vasospasm and restricted blood flow in his medical school thesis in 1862. Raynaud's phenomenon is common and exists as an uncomplicated primary Raynaud phenomenon and a Raynaud phenomenon secondary to underlying diseases and medication. Mechanisms contributing to altered vasoconstrictor activity are endothelial and not-endothelial. Cold-induced vasospasm is probably a thermoregulatory problem and effects are mediated by sympathetic activity and selective stimulation of alpha2c-adrenoreceptors.© Georg Thieme Verlag KG Stuttgart · New York.

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