• Dtsch. Med. Wochenschr. · Jan 2020

    Case Reports

    [Complete remission of Loeffler's endocarditis with Imatinib in a myeloid and lymphoid neoplasm associated with eosinophilia].

    • Hendrik Wienemann, Paul J Bröckelmann, and Matti Adam.
    • Klinik III für Innere Medizin, Herzzentrum, Universität zu Köln.
    • Dtsch. Med. Wochenschr. 2020 Jan 1; 145 (1): 36-39.

    History And Clinical FindingsA 53-year-old male presented with massive pruritus, whole-body exanthema, generalized muscle pain, and exercise dyspnoea NYHA II.Findings And DiagnosisFurther hematologic examination lead to diagnosis of myeloid and lymphoid neoplasia with eosinophilia (MLN-EO) with FIPL1L1-PDGFRA fusion gene. An echocardiographic examination revealed a thrombus in the right ventricle. Magnetic resonance imaging (MRI) showed an extensive intracavitary thrombus extending from the apex to the right ventricular outflow tract.Therapy And CourseOral anticoagulation with phenprocoumon and a targeted therapy with imatinib were initiated. Follow-up at 11- and 23-months revealed diminishing of the thrombus. Further follow-up did not show any complications.ConclusionsIn summary, Loeffler's endocarditis caused by a myeloid and lymphoid neoplasm associated with eosinophilia and abnormalities of FIP1L1-PDGFRA rearrangement could be treated successfully with oral anticoagulation therapy and the tyrosine-kinase inhibitor imatinib.© Georg Thieme Verlag KG Stuttgart · New York.

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