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Dtsch. Med. Wochenschr. · Apr 2020
Case Reports[Acute exacerbation of reactivated chronic hepatitis-b after stopping antiviral medication followed by loss of HBsAg].
- Florian Bert and Siegbert Rossol.
- Department of internal medicine, Krankenhaus Nordwest, Frankfurt/Main, Germany.
- Dtsch. Med. Wochenschr. 2020 Apr 1; 145 (8): 552-554.
History And Clinical FindingsA 66-year-old women with chronic hepatitis-b and antiviral therapy was presented with icterus and sickness 2 weeks after cold symptoms. The treatment was stopped by patient 6 month before. The liver was enlarged, the abdomen and further body status unsuspicious.Findings And DiagnosisThe chemical results showed elevated liver enzymes and bilirubin values. The hepatitis-b status revealed signs of chronical course (HBsAg positive), the virus amount was > 21 Mio IU/ml. The sonographic abdominal status was normal.Therapy And CourseThe antiviral therapy was re-established and liver enzymes improved. The virus amount was falling and after 22 weeks antiviral therapy seroconversion (HBsAg negative) and healing up of hepatitis-b was objectified.ConclusionAcute exacerbation of chronic hepatitis-b followed stopping antiviral treatment can lead to healing by loss of HBsAg.© Georg Thieme Verlag KG Stuttgart · New York.
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