• Fei Fei Liu, Hui Hui Liu, Zhen Qiu, Jing Jing Wang, Sama Samadli, Yue Wu, Yang Fang Wu, Yao Xu, Huang Huang Luo, Wei Xia Chen, Dong Dong Zhang, and Peng Hu.
• Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
• Eur. J. Clin. Invest. 2020 Apr 1; 50 (4): e13210.

BackgroundKawasaki disease (KD) is an acute, self-limited vasculitis. Coronary artery aneurysm (CAA) serves as a major contributor to the long-term prognosis of KD. In addition, acute KD usually also leads to several kinds of noncoronary cardiac abnormalities (NCA) involving the pericardium, myocardium and endocardium.Materials And MethodsA total of 142 Chinese children with KD were recruited from July 2015 to April 2018. Blood samples were collected at 24 hours pre-intravenous immunoglobulin (IVIG) therapy. Several inflammatory mediators and biomarkers for acute myocardial infarction were detected. Echocardiography and electrocardiography (ECG) were performed.ResultsPlasma white blood cell counts (WBC) were significantly increased in patients with IVIG-nonresponsive KD when compared with their IVIG-responsive counterparts. A total of 106 children (74.65%) suffered from NCA, including 8 patients (5.63%) with pericardial effusion, 23 patients (16.20%) with acute myocarditis, 101 patients (71.13%) with valvular regurgitation and 8 patients (5.63%) with abnormal ECG. No significant differences were observed in the distribution of clinical classification and the response to IVIG therapy regardless of NCA exhibited or not.ConclusionsNoncoronary cardiac abnormalities is almost universal in acute KD and mainly manifests as valvular regurgitation. However, it has no influence on clinical classification and the response to IVIG therapy.© 2020 Stichting European Society for Clinical Investigation Journal Foundation.

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