• Eur. J. Clin. Invest. · Jun 2020

    Review

    Neutrophil recruitment and intracellular vesicle transport: A short overview.

    • Sergi Masgrau-Alsina, Markus Sperandio, and Ina Rohwedder.
    • Institute of Cardiovascular Physiology and Pathophysiology, Ludwig-Maximilians-University Munich, Planegg-Martinsried, Germany.
    • Eur. J. Clin. Invest. 2020 Jun 1; 50 (6): e13237.

    AbstractRecruitment of neutrophils from the intravascular compartment into injured tissue is an essential component of the inflammatory response. It involves intracellular trafficking of vesicles within neutrophils and endothelial cells, both containing numerous proteins that have to be distributed in a tightly controlled and precise spatiotemporal fashion during the recruitment process. Rab proteins, a family of small GTPases, together with their effectors, are the key players in guiding and regulating the intracellular vesicle trafficking machinery during neutrophil recruitment. This review will provide a short overview on this process and highlight new findings as well as current controversies in the field.© 2020 The Authors. European Journal of Clinical Investigation published by John Wiley & Sons Ltd on behalf of Stichting European Society for Clinical Investigation Journal Foundation.

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