• Der Internist · Jul 2020

    Review

    [New pharmacological treatment options for nonalcoholic fatty liver disease].

    • Norbert Stefan.
    • Klinisch-experimentelle Diabetologie, Abteilung für Innere Medizin IV, Bereiche Endokrinologie, Diabetologie und Nephrologie, Universitätsklinikum Tübingen, Otfried-Müller-Str. 10, 72076, Tübingen, Deutschland. norbert.stefan@med.uni-tuebingen.de.
    • Internist (Berl). 2020 Jul 1; 61 (7): 759-765.

    AbstractThe prevalence of nonalcoholic fatty liver disease (NAFLD) continues to increase worldwide, presently affecting 25% of the adult population, and is associated with an elevated risk of total and liver-specific mortality. NAFLD is a chronic disease and results from a combination of genetic, environmental and predominantly lifestyle-related causes. Therefore, NAFLD, similarly to cardiovascular disease, type 2 diabetes and many different types of cancer, can be considered a noncommunicable disease. Consequently, lifestyle intervention, particularly if associated with a large amount of weight loss, is considered highly effective and safe to treat NAFLD. For patients with advanced-stage NAFLD or that cannot lose weight, metabolically-based pharmacotherapy is effective to improve liver histology and cardiometabolic risk profile. If a moderate or advanced stage of liver fibrosis is present, additional antifibrotic therapy is necessary to halt the progression of the disease.

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