• Sami El-Dalati, Daniel Cronin, Michael Shea, Richard Weinberg, James Riddell, Laraine Washer, Emily Shuman, James Burke, Sadhana Murali, Christopher Fagan, Twisha Patel, Kirra Ressler, and George Michael Deeb.
• Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor. Electronic address: seldalat@med.umich.edu.
• Am. J. Med. 2020 Jan 1; 133 (1): 44-49.

AbstractInfectious endocarditis is a highly morbid disease with approximately 43,000 cases per year in the United States. The modified Duke Criteria have poor sensitivity; however, advances in diagnostic imaging provide new tools for clinicians to make what can be an elusive diagnosis. There are a number of risk stratification calculators that can help guide providers in medical and surgical management. Patients who inject drugs pose unique challenges for the health care system as their addiction, which is often untreated, can lead to recurrent infections after valve replacement. There is a need to increase access to medication-assisted treatment for opioid use disorders in this population. Recent studies suggest that oral and depo antibiotics may be viable alternatives to conventional intravenous therapy. Additionally, shorter courses of antibiotic therapy are potentially equally efficacious in patients who are surgically managed. Given the complexities involved with their care, patients with endocarditis are best managed by multidisciplinary teams.Copyright © 2019 Elsevier Inc. All rights reserved.

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