• Am. J. Med. · Aug 2020

    Observational Study

    Profile of Patients Diagnosed with Acute Venous Thromboembolism in Routine Clinical Practice: The RE-COVERY DVT/PE™ Study.

    • Samuel Z Goldhaber, Walter Ageno, Ivan B Casella, Kok Han Chee, Sebastian Schellong, Daniel E Singer, Marc Desch, Paul A Reilly, Esther Donado, Wenbo Tang, Isabelle Voccia, and Sam Schulman.
    • Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address: sgoldhaber@partners.org.
    • Am. J. Med. 2020 Aug 1; 133 (8): 936-945.

    BackgroundThe safety and efficacy of nonvitamin K antagonist oral anticoagulants (NOACs) for the treatment of venous thromboembolism (VTE) have been established in randomized controlled trials, but limited data are available on their use in clinical practice across geographical regions.MethodsIn the international RE-COVERY DVT/PE observational study (enrollment January 2016 to May 2017), we sought to characterize the patient population and describe the prescribed anticoagulant. Patient characteristics and anticoagulants administered after objective diagnosis of VTE were recorded at the baseline visit and again at hospital discharge or at 14 days after the diagnosis, whichever was later.ResultsA total of 6095 patients were included, 50.2% were male, and the mean age was 61.5 years. The most common comorbidities were hypertension (35%), diabetes mellitus (11%), cancer (11%), prior VTE(11%), and trauma/surgery (7%). Overall, 77% of patients received oral anticoagulants, with 54% on NOACs and 23% on vitamin K antagonists (VKAs); 20% received parenteral anticoagulation only. NOACs comprised about 60% of anticoagulant treatment in Europe and Asia but substantially less in Latin America (29%) and the Middle East (21%). For NOAC therapies, the distribution (as a percentage of the total cohort) was rivaroxaban 25.6%, dabigatran 15.5%, apixaban 11.3%, and edoxaban 1.7%. Treatment with NOACs was less frequent in patients who had cancer, chronic renal disease, heart failure, or stroke.ConclusionsThese findings enhance our understanding of baseline characteristics and the initial management of patients with VTE in routine practice.Copyright © 2020 Elsevier Inc. All rights reserved.

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