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- Lucy Lowery, Inga Andrew, Sarah Gill, and Mark Lee.
- St Benedict's Hospice, Sunderland, UK.
- Palliat Med. 2014 Jul 1; 28 (7): 990-991.
BackgroundThis case report describes a patient whose refractory nausea and vomiting significantly improved with the use of aprepitant, a neurokinin receptor antagonist currently only licensed for short-term use in chemotherapy-induced nausea and vomiting.Case PresentationA patient with breast cancer and meningeal metastases had an 18-month history of nausea and vomiting refractory to a number of antiemetics commonly used in palliative care. The nausea and vomiting resolved after receiving two doses of the drug aprepitant.Case Management And OutcomeMaintenance antiemetic treatment with aprepitant was continued over a 5-month period with no recurrence of nausea and vomiting, and no observed side effects.ConclusionsAprepitant has a potential role as an antiemetic for refractory symptoms within the palliative-care setting.© The Author(s) 2014.
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