• Curr Med Res Opin · Apr 2020

    Osteocalcin in acute stress response: from the perspective of cardiac diseases.

    • Aiju Tian, Chengzhi Yang, and Zening Jin.
    • Department of Cardiology, Beijing Geriatric Hospital, Beijing, China.
    • Curr Med Res Opin. 2020 Apr 1; 36 (4): 545-546.

    AbstractOsteocalcin is an osteoblast-derived peptide mainly found in the bone matrix but also in circulation. A recent investigation suggested that osteocalcin mediated acute stress response (ASR) by inhibiting parasympathetic tone in mice and humans. We propose a hypothesis that osteocalcin is regulated by the skeleton movement and glucocorticoids, and inhibition of the parasympathetic tone by osteocalcin may indicate a therapeutic target in the treatment of acute myocardial infarction (AMI).

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